Aging

Doctors use lasers and retinoic acid to treat skin damage. Scientists have now uncovered a common mechanism that links both, paving the way for new treatments. What links laser and retinoic acid treatment for sun damage? Skin damage, in the form of dark spots and wrinkles, naturally occurs as we age. Ultraviolet light from the
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As women get older, they tend to have less sex. They may also find it less enjoyable than before. So far, studies have explained these tendencies by pointing the finger at physiological changes during and after menopause. What are the other factors? What prevents a woman from having sex or enjoying sex later in life?
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The buildup of defective tau proteins is a prominent feature of neurodegenerative diseases such as Alzheimer’s. The faulty proteins form tangles that disrupt brain function and kill nerve cells, or neurons. Experiments in human cell cultures reveal a mechanism through which scientists can regulate defective tau protein levels. Now, scientists have identified a molecule that
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Large-scale research suggests that drinking alcohol in older age may lower mortality risk. However, the scientists are cautious about potential biases in their own research and say that more research is necessary. Does moderate drinking in older age have any health benefits? A new study investigates. The debate around the potential health benefits of alcohol
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In this Spotlight, we introduce the glymphatic system: the brain’s dedicated waste clearance system. Now implicated in various conditions, it is high time that we became acquainted. Astroglia (illustrated above) play a pivotal role in the brain’s trash collection service. Many of us are relatively familiar with the lymphatic system; it performs a number of
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Researchers reveal a marker and new testing tool of frontotemporal dementia that may help distinguish this condition from Alzheimer’s disease. ‘Moral emotions’ are ones that prompt us to do good and contribute to pro-social behavior and cooperation. Frontotemporal dementia (FTD) is a less common form of dementia than Alzheimer’s. Sometimes called Pick’s disease or frontal
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A recent study concludes that social interaction might be more than just a pleasant pastime; it might help doctors predict an individual’s risk of cognitive decline and, perhaps, dementia. How does social interaction influence cognitive decline? Cognitive decline refers to a general reduction in mental abilities over time. It affects many people as they age
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A large study concludes that atrial fibrillation does, indeed, raise the risk of dementia even in people who did not have a stroke and that anticoagulants may reduce this risk. An irregular heartbeat may be a sign of A-fib, which may, in turn, raise dementia risk. Atrial fibrillation (A-fib) is a condition in which the
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Researchers have designed a brain aging model to investigate the factors that contribute to cognitive decline, borrowing principles from precision medicine. How can we tackle cognitive decline? Cognitive decline affects a person’s ability to focus, remember, and make decisions. Its severity can range from mild to severe, and it may lead to dementia, in the
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Researchers have found that nilvadipine, a drug that doctors regularly use to treat hypertension, may help people with Alzheimer’s disease by increasing blood flow to the brain. New research suggests that a high blood pressure drug may slow down the progression of Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia. This progressive
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For many years, specialists believed that people who studied more and kept their brains more active had lower dementia risk. Some recent studies have contradicted this idea. So how is education linked to the evolution of Alzheimer’s disease, if at all? Another study suggests that there is no link between a person’s level of education
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Millions of people die prematurely each year due to noncommunicable diseases, some of the most common of which are cardiovascular diseases. New research from Harvard suggests that three tried and tested interventions could prevent many of those deaths if implemented through global policies. Three global interventions could prevent millions of deaths over the next couple
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There are two major stumbling blocks to developing effective drugs for Alzheimer’s, Parkinson’s, and other diseases that destroy the brain. The first is overcoming the blood-brain barrier, and the second is delivering the drug to a precise location and ensuring that it does not spread to the rest of the brain. New research finds a
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Evidence indicates that following a Mediterranean-style diet, rich in fruit, vegetables, nuts, and cereals, can bring many health benefits, including protection against cardiovascular and metabolic problems. Now, a study also presents a link between this diet and a lower risk of depression later in life. New research finds a link between Mediterranean-style diets and a
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New research identifies changes in the neurochemistry and anatomy of the brain that occur decades before people experience any symptoms of Alzheimer’s disease. Brain changes may occur decades before people experience Alzheimer’s symptoms, accumulating evidence suggests. The fact that more than 35 million people are currently living with Alzheimer’s disease has led some experts to
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Research in mice now shows that a specific cell death mechanism can lead to rheumatoid arthritis. Stopping this mechanism could help prevent this condition from developing, the authors argue. Researchers uncover a key cellular mechanism involved in RA that has potential therapeutic implications. Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized mainly by pain
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A new drug for treating Alzheimer’s disease has successfully passed the first phase of testing in humans. Preclinical studies had already shown that the drug could improve memory and other symptoms of Alzheimer’s disease in older mice. A potential treatment for Alzheimer’s moves a step closer. Researchers at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf,
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